As problem solvers, analysts search for ways to optimize their experiments and quickly collect data. With HALO® UHPLC and HPLC columns for small molecule analysis, this process is made simpler and less problematic.
From an ultra-fast separation of a few compounds to a more complex natural product sample containing hundreds of analytes, HALO® columns offer an optimized solution for separation challenges.
Discover more with Fused-Core® small molecule Columns:
- High-speed, high-resolution separations enabling reproducible and reliable results
- Unmatched quality of manufacturing
- Optimized pore size
- Three particle size choices to accommodate all HPLC, UHPLC, and MS instruments
- Wide portfolio of bonded phases for reversed phase and HILIC separations
Available Particles
![90a-2 halo particle](https://halocolumns.com/wp-content/uploads/2021/04/90a-2.png)
BEST USES
Best all-purpose rugged particle providing high efficiencies with minimal back pressure.
PERFORMANCE POTENTIAL
230,000+ plates/meter
EFFICIENCY COMPARISON TO FPP
Performance of <2 µm FPP
INSTRUMENTATION
UHPLC/HPLC
![c18 column performance for small molecule analysis](https://halocolumns.com/wp-content/uploads/2021/04/small-molecule-2.7-1.png)
![90a-3 halo particle](https://halocolumns.com/wp-content/uploads/2021/04/90a-3.png)
BEST USES
Complex separations when ultimate resolution is required with a low system volume UHPLC.
PERFORMANCE POTENTIAL
300,000+ plates/meter
EFFICIENCY COMPARISON TO FPP
Outperforms <2 µm FPP
INSTRUMENTATION
UHPLC
AVERAGE OF 57% TALLER PEAKS AT 15% LOWER PRESSURE COMPARED TO FPP!
![halo c18 column pressure vs fpp column pressure](https://halocolumns.com/wp-content/uploads/2021/04/small-molecule-2um-1.png)
![90a-1 halo particle](https://halocolumns.com/wp-content/uploads/2021/04/90a-1.png)
BEST USES
When more performance or lower back pressures from 3 µm or 5 µm FPP methods are desired; samples with dirty matrices.
PERFORMANCE POTENTIAL
160,000+ plates/meter
EFFICIENCY COMPARISON TO FPP
Performance of 3 µm FPP
INSTRUMENTATION
HPLC
60% IMPROVED EFFICIENCY AND 1/2 THE SEPARATION TIME COMPARED TO FPP!
![small molecule analysis](https://halocolumns.com/wp-content/uploads/2021/04/small-molecule-5um-1.png)
SMALL MOLECULE MARKETS WE SERVE
HALO® Fused-Core® Technology enables fast and efficient separations for laboratories across multiple market segments. Click below to explore each.