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Glycans are simple and complex carbohydrates (sugars) that influence protein structure/folding and transport. Glycosylation is one of the most important modifications of the protein structure.

Given the importance of glycosylation to the overall performance of a glycoprotein, there is a need to completely characterize and then monitor these glycans for both research and manufacturing purposes.

HALO® BIOCLASS glycan columns deliver:

  • Each lot of HALO® Glycan material is quality assurance tested for application performance
  • Ideal for hydrophilic interaction liquid chromatography (HILIC) separations of oligosaccharides, and particularly, of released and labeled glycans from glycoproteins and proteoglycans
  • A highly polar ligand that contains 5 hydroxyl groups tethered to 2.7 µm Fused-Core® silica particles via novel, proprietary linkage chemistry
  • Improved retention of acidic and zwitterionic analytes
AMT-BioClass-glycan-white

Available Particles

BEST USES

Oligosaccharides, glycans, acidic and zwitterionic analytes

BONDED PHASE

Proprietary poly-hydroxy

PORE SIZE

90 Å

APPLICATION ASSURED

Example QA chromatogram for HALO® Glycan column. Each HALO® Glycan packing lot is tested using this glycan ladder mixture to assess and ensure lot-to-lot reproducibility.

Featured Documents

Application Notes

Technical Literature

Catalog

Guidebook

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