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Advancing the understanding of form and function for biomolecules. Researchers supporting their development and release employ many orthogonal techniques and separation methodologies to develop a more complete therapeutic picture.

With both tailored particle and pore size options, HALO® BIOCLASS offers application-specific solutions for:

  • Intact proteins, monoclonal antibodies (mAbs), biosimilars, and other large biomolecules such as pegylated proteins, antibody-drug conjugates (ADCs), etc.
  • Peptide mapping (analysis of enzyme digests) for characterization and monitoring of synthetic protein drugs
  • Analysis of therapeutic peptides and peptide biomarkers (protein surrogates)
  • High-resolution separations of complex mixtures of glycans released from N- and O-linked glycoproteins
bioclass for protein separations
  • Wide pore portfolio for unrestricted bonded phase access capable of characterizing very large proteins with good peak shape and recovery
  • Compatible chemistries for UHPLC, HPLC, and Mass Spectrometry
  • Variety of bonded phase options for a tailored solution
peptide separations
  • SPP technology for fast, high-resolution peptide separations
  • High peak capacities delivering rugged, reliable performance for use with either UHPLC, HPLC, or LC-MS
  • Extensive portfolio of particle sizes and chemistries
glycan analysis
  • Improved retention of acidic and zwitterionic analytes
  • Very low sensitivity to buffer concentration
  • Able to separate isobaric oligosaccharides with different linkages

Featured Documents

Application Notes

Technical Literature

Catalog

Halo Bioclass For Glycan Analysis, Protein Separation And Peptide Separation

Guidebook

Halo Columns Bioanalysis Solutions Guidebook
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