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Advancing the understanding of form and function for biomolecules. Researchers supporting their development and release employ many orthogonal techniques and separation methodologies to develop a more complete therapeutic picture.

With both tailored particle and pore size options, HALO® BIOCLASS offers application-specific solutions for:

  • Intact proteins, monoclonal antibodies (mAbs), biosimilars, and other large biomolecules such as pegylated proteins, antibody-drug conjugates (ADCs), etc.
  • Peptide mapping (analysis of enzyme digests) for characterization and monitoring of synthetic protein drugs
  • Analysis of therapeutic peptides and peptide biomarkers (protein surrogates)
  • High-resolution separations of complex mixtures of glycans released from N- and O-linked glycoproteins
  • Wide pore portfolio for unrestricted bonded phase access capable of characterizing very large proteins with good peak shape and recovery
  • Compatible chemistries for UHPLC, HPLC, and Mass Spectrometry
  • Variety of bonded phase options for a tailored solution
  • SPP technology for fast, high-resolution peptide separations
  • High peak capacities delivering rugged, reliable performance for use with either UHPLC, HPLC, or LC-MS
  • Extensive portfolio of particle sizes and chemistries
  • Improved retention of acidic and zwitterionic analytes
  • Very low sensitivity to buffer concentration
  • Able to separate isobaric oligosaccharides with different linkages

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