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New Dimension in Chromatography - Halo® 1.5

The New HALO® PCS C18 – Positively Exceptional Performance

Built upon proven Fused-Core® technology for speed and efficiency, the HALO® PCS C18 is a positively charged surface chemistry designed to deliver improved peak shapes for basic compounds.  Ideal for use with low ionic strength mobile phases, HALO® PCS maintains peak symmetry at higher loading capacities and provides an alternate selectivity for other C18 bonded phases.  Available in both a 90 Å and 160 Å pore size for small molecule and peptide analysis.

Delivering More Performance

In the realm of chromatography, the HALO® PCS C18 columns set a new benchmark. Merging precision with efficiency, these columns are crafted to offer unparalleled performance in various analytical applications. Key features include:


Excellent Peak Shape and Increased Loading Capacity for basic compounds


UHPLC and LCMS Compatible


Alternate L1 Selectivity


Built upon Fused-Core® Technology for fast, efficient and reliable separations

The Positively Charged Surface Advantage

A synthetic panel of basic peptides is screened on the HALO 160 Å PCS C18 compared to the traditional C18 stationary phase. While using low ionic strength mobile phases such as formic acid the positively charged surface stationary phase shows significantly better peak widths and symmetry for more basic peptides when compared to a traditional non-endcapped peptide C18 stationary phase.

Looking for a PCS C18 Column Tailored to Your Needs?

The HALO® PCS C18 columns offer a spectrum of characteristics ensuring unparalleled performance. Perfectly suited for a range of applications from pharmaceuticals to steroids, fatty acids, phthalates, and environmental studies, these C18 columns stand out. The HALO® Fused-Core® PCS technology tolerates a higher sample load of basic compounds compared to the competitor fully porous C18 column. The PCS stationary phase is ideal for basic analytes when using low ionic strength mobile phases such as formic acid.

Best Applications:

  • Reversed-phase separations of basic analytes prone to peak tailing
  • Peptide mapping
  • Basic pharmaceutical compounds

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taking advantage of fused-core® technology

Visit our solutions pages to learn more about the best uses and benefits of Fused-Core® Technology.

hplc columns for small molecule analysis

From an ultra-fast separation of a few compounds to a more complex natural product sample containing hundreds of analytes, HALO® columns offer an optimized solution for separation challenges.

lc column for biopharma solutions

Biopharmaceuticals are inherently more complex than small molecules. HALO® BioClass columns have been specifically designed to accomplish these bio-separation goals with a simplified and more effective solution.

hplc environmental applications

Solutions for other persistent, high environmental-impact contamination agents such as pesticides, mycotoxins, herbicides, and more all based upon HALO’s 15 years of innovative and trusted technology.

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