The New HALO® 1.5 – Defining a New Dimension in Chromatography
The adoption of UHPLC instrumentation pushed LC separations to a new level of speed and resolution. In the years since, chromatographers continue to push separation limits in response to increasing challenges.
How can I improve my separation in a faster time, or with less solvent consumption, increased sensitivity, or all of the above? While the specific drivers may be different, the overall goal is the same – “I need more, but without sacrificing anything”.
Delivering More Performance
More Sensitivity from conventional UHPLC Systems
Higher Ionization Efficiencies from LCMS systems
Reduce Solvent Consumption compared to 2.1 mm ID columns
Easy to Implement microflow solution
NEW Featured Documents
Technical Documents
Application Notes
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More Sensitivity
- Increased detector signal response from UHPLC and LCMS systems
- >2x peak areas compared to 2.1 mm (and larger) id columns
- Higher efficiencies compared to 1 mm id columns on UHPLC systems
Reduced & Alkylated mAb Shows >2x Signal Intensity
Comparison of New 1.5 mm vs 2.1 mm ID for OTC Cough & Cold Medicines
*see brochure for full test conditions
Solvent Reduction
- Reduced internal diameter leads to lower optimal flow rates reducing solvent consumption
- Decreased solvent waste removal costs
- Less environmental impact
Peptide Map Solvent Savings Using HALO 160 Å ES-C18 in 1.5 mm ID
*see brochure for full test conditions
Stability
- New 1.5 mm id hardware demonstrated excellent lot to lot reproducibility
- Stability testing delivers RSD’s <0.3% with no loss in efficiency or retention
- Manufactured in Advanced Materials Technology’s ISO 9001 certified facility
Stability of 1000 Injections on HALO 90 Å C18 in 1.5 mm ID
Excellent Lot to Lot Reproducibility
*see brochure for full test conditions
System Optimization
- System optimization helps to ensure the best performance
- Reducing UHPLC system contributors to extra column diffusion further enhances performance
- Connection tubing is a large contributor to dispersion and can be easily exchanged for volume reduction
- The use of MarvelXACT® finger-tight UHPLC connectors with volume definitions easily identifies the connection tubing volume contribution and ensures zero dead volume
Impact of Extra Column Dispersion on Column ID’s Using an Optimized UHPLC System
Products Available in 1.5 mm
SMALL MOLECULE
PEPTIDE
PROTEIN
HPLC ACCESSORIES
ENSURE A PERFECT CONNECTION WITH MarvelXACT™
MarvelXACT™ connection systems have been designed to eliminate the risk of under- or over-tightening with a patented torque limiting mechanism. This unique feature emits a haptic “click” feedback when it reaches the optimum torque, assuring a perfect installation every time. MarvelXACT™ incorporates advanced MarvelX™ Sealing Technology to deliver precise face sealing (sealing at the port bottom), which eliminates additional internal volume, and minimizes carryover risk, peak tailing, and peak broadening.
MarvelXACT and MarvelX are registered trademarks of IDEX
AMT MarvelXACT™ Connection Tubing
$180.00 – $370.00
Description
- Advanced Materials Technology’s MarvelXACT® finger-tight UHPLC connectors with volume definitions easily identifies dispersion volume contribution
- Haptic “click” indicates optimum torque and zero dead volume connection
- Connector and tubing for both pre and post column installation
- Available in both PEEKsil® and PEEK lined stainless steel materials
MarvelXACT and MarvelX are registered trademarks of IDEX
- Finger-tight connection up to 19,000 psi (~1310 bar)
- 1/32” OD tubing
- PEEKsil® and PEEK lined stainless steel
- Available in id’s of 25 µm, 50 µm, 75 µm, and 100 µm
- Available in lengths of 150 mm, 350mm, and 600 mm
taking advantage of fused-core® technology
Visit our solutions pages to learn more about the best uses and benefits of Fused-Core® Technology.
From an ultra-fast separation of a few compounds to a more complex natural product sample containing hundreds of analytes, HALO® columns offer an optimized solution for separation challenges.
Biopharmaceuticals are inherently more complex than small molecules. HALO® BioClass columns have been specifically designed to accomplish these bio-separation goals with a simplified and more effective solution.
Solutions for other persistent, high environmental-impact contamination agents such as pesticides, mycotoxins, herbicides, and more all based upon HALO’s 15 years of innovative and trusted technology.