AUTHOR: Conner McHale, Technical Support Specialist, Advanced Materials Technology INTRODUCTION to PFAS ANALYTICAL METHODS Per- and polyfluoroalkyl substances (PFAS) are a group of chemicals used to make fluoropolymer coatings and products that resist heat, oil, stains, grease, and water. These…
The goal for chromatographic separations is to achieve well resolved peaks with adequate retention and demonstrate gaussian peak shapes, so the compounds being separated can be assessed accurately both qualitatively and quantitatively. Peak shape is one of the most common…
Introduction A revolutionary innovation in liquid chromatography occurred in 2006 when Advanced Materials Technology introduced the first sub-3-µm superficially porous particles (SPP) and columns designed for HPLC and UHPLC of small molecules such as pharmaceuticals, industrial chemicals, and the like.…
AUTHOR: Andrew Harron Ph.D., Application Scientist MARKET SEGMENT: BIOCLASS ABSTRACT Decreasing the internal diameter of a column can increase detector response, lower solvent consumption, and bring multiple benefits to the overall analysis workflow. This has fueled the development of capillary…
Author: Dr. Stephanie Schuster, Senior Technical Support Scientist from Advanced Materials Technology For more information, please contact: [email protected] INTRODUCTION The guidelines in United States Pharmacopeia (USP) Chapter <621> were recently updated to allow changes to particle size and column dimensions…
Using 1.5 mm ID Columns for Solvent Reduction While Increasing Sensitivity Originally, HPLC methods were developed using 4.6 mm ID columns and greater. At the time, the separations were acceptable, and not much emphasis was placed on either reducing solvent…
AUTHOR: Stephanie Schuster, Ph.D., Senior Technical Support Scientist ABSTRACT The new HALO® 1.5 mm ID columns offer an alternative to analytical and narrow bore columns for greater separation performance with the benefits of increased sensitivity, reduced solvent consumption/reduced waste disposal costs,…
Introduction High-pressure liquid chromatography (HPLC) is a benchmark technique used in laboratories across the world. However, even experienced analysts that are familiar with HPLC concepts and principles can fall victim to chromatographic pitfalls that arise. Some common issues include misshapen…
THE POSITIVES OF PCS The new HALO®PCS C18 phase offers an alternative to chromatographic separations under acidic conditions. Many chromatographers are familiar with the difficulties of separating basic compounds. These compounds are troublesome and usually elute from the column with…
Amino acid analysis (AAA) is an important technique for determining the quantity of amino acids in a sample. In the biopharmaceutical industry, amino acid analysis has become an important tool in quantifying amino acid content in both feed and spent…
Some exclusions apply.
See the promotions page for details.
